Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:2384500 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
238472723875042778viral enhancin proteinQuickGO ontologyBLASTP
238794623898171872cadmium-exporting ATPaseQuickGO ontologyBLASTP
23899992390274276hypothetical proteinBLASTP
23903972390687291bacterial microcompartments family proteinQuickGO ontologyBLASTP
23907612391411651propanediol utilization protein PduL homologQuickGO ontologyBLASTP
239141123930091599acetaldehyde dehydrogenase acetylatingQuickGO ontologyBLASTP
23930442393841798bacterial microcompartments family proteinQuickGO ontologyBLASTP
23938622394524663ethanolamine utilization protein EutQ homologQuickGO ontologyBLASTP
23947232394986264putative polyhedral organelle formation proteinQuickGO ontologyBLASTP
23949832395285303hypothetical proteinBLASTP
23953632396208846ethanolamine utilization protein EutJ family proteinQuickGO ontologyBLASTP
23961902396918729hypothetical proteinBLASTP
23969252397371447GTP-binding protein EutPPduV familyQuickGO ontologyBLASTP
23973682397721354ethanolamine utilization protein EutS homologQuickGO ontologyBLASTP
23977612398714954glycyl-radical enzyme activating family proteinQuickGO ontologyBLASTP
239887824014182541formate acetyltransferaseQuickGO ontologyBLASTP
240146824029611494aldehyde dehydrogenase family proteinQuickGO ontologyBLASTP