Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:2203037 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
220117822030401863ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
220303722053642328putative ABC transporter ATP-bindingpermease proteinQuickGO ontologyBLASTP
22057682206211444transcriptional regulator MarR familyQuickGO ontologyBLASTP
22065232207206684molybdopterin biosynthesis protein MoeBQuickGO ontologyBLASTP
22072082207435228molybdopterin converting factor subunit 1QuickGO ontologyBLASTP
220758822094051818aldehyde ferredoxin oxidoreductase tungsten-containingQuickGO ontologyBLASTP
220981422117091896aor transcriptional regulatorQuickGO ontologyBLASTP
22117592212199441MOSC domain proteinQuickGO ontologyBLASTP
22122012212680480molybdenum cofactor biosynthesis protein CQuickGO ontologyBLASTP
22126842213643960molybdenum cofactor biosynthesis protein AQuickGO ontologyBLASTP
221370222156061905molybdopterin cofactor synthesisbinding domain proteinQuickGO ontologyBLASTP
221561822168441227molybdopterin biosynthesis enzyme MoeAQuickGO ontologyBLASTP
22168682217356489molybdopterin biosynthesis enzyme MogQuickGO ontologyBLASTP
22174512218143693tungstate ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
22181402218811672tungstate ABC transporter permease proteinQuickGO ontologyBLASTP
22188202219671852tungstate ABC transporter tungstate-binding proteinQuickGO ontologyBLASTP
221989022212121323MATE efflux family proteinQuickGO ontologyBLASTP
22212122221409198hypothetical proteinBLASTP
22216502222294645hypothetical proteinBLASTP
22226162223287672ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
222330222247651464ABC transporter permease proteinQuickGO ontologyBLASTP