Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:2101449 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
21014492102027579hypothetical proteinBLASTP
21027062103293588hypothetical proteinBLASTP
21034222104180759N-acetylmuramoyl-L-alanine amidaseQuickGO ontologyBLASTP
21041802104353174hypothetical proteinBLASTP
21043552104579225hypothetical proteinBLASTP
21047912105270480hypothetical protein
21055192105926408hypothetical protein
21060212106188168hypothetical proteinBLASTP
21061902106516327hypothetical proteinBLASTP
210652821079851458hypothetical proteinBLASTP
210799221091491158hypothetical proteinBLASTP
21091532110022870hypothetical proteinBLASTP
211003821139643927phage tail tape measure protein familyQuickGO ontologyBLASTP
21140212114140120hypothetical proteinBLASTP
21142542114646393hypothetical proteinBLASTP
21147042115285582phage major tail protein Phi13 familyQuickGO ontologyBLASTP
21153492115705357hypothetical proteinBLASTP
21157212116080360phage protein HK97 gp10 familyQuickGO ontologyBLASTP
21160812116449369phage head-tail adaptor proteinQuickGO ontologyBLASTP
21164392116732294hypothetical proteinBLASTP
211681721180491233phage major capsid protein HK97 familyQuickGO ontologyBLASTP
21181022118845744serine proteaseQuickGO ontologyBLASTP
211883821200881251phage portal protein HK97 familyQuickGO ontologyBLASTP