Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:1704345 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
170434517056011257phage portal protein HK97 familyQuickGO ontologyBLASTP
17055881706349762serine proteaseQuickGO ontologyBLASTP
170638817075631176phage major capsid protein HK97 familyQuickGO ontologyBLASTP
17076081707865258hypothetical proteinBLASTP
17078841708219336hypothetical proteinBLASTP
17082291708438210hypothetical protein
17084411708854414hypothetical proteinBLASTP
17089151709340426hypothetical protein
17095431709833291hypothetical proteinBLASTP
170983817109231086hypothetical proteinBLASTP
17109341711362429hypothetical proteinBLASTP
17113781711797420hypothetical proteinBLASTP
17118661711997132hypothetical protein
171203317146632631phage tail tape measure protein TP901 family core regionQuickGO ontologyBLASTP
17147101715141432hypothetical proteinBLASTP
17151411716073933hypothetical proteinBLASTP
17160841716401318hypothetical protein
17164131716850438hypothetical proteinBLASTP
171686217179711110hypothetical proteinBLASTP
17179831718513531hypothetical proteinBLASTP
17185241719330807hypothetical proteinBLASTP
17193461719651306hypothetical proteinBLASTP
17196671719852186hypothetical proteinBLASTP
17199401720143204bacteriocin UviBQuickGO ontologyBLASTP
17201451720318174hypothetical proteinBLASTP
17203611721119759bacteriophage endolysinQuickGO ontologyBLASTP
17214431721595153hypothetical protein
17215821721764183hypothetical proteinBLASTP
17217751722020246putative lipoproteinQuickGO ontology
17221651722671507hypothetical protein
17228281723316489hypothetical proteinBLASTP
17234131724051639hemolysin IIIQuickGO ontologyBLASTP
172417217252691098GTP-binding protein YchFQuickGO ontologyBLASTP
17259631726433471mraZ proteinQuickGO ontologyBLASTP
17265131727442930S-adenosyl-methyltransferase MraWQuickGO ontologyBLASTP
17275241728027504putative cell division protein FtsLQuickGO ontologyBLASTP
172804317302232181stage V sporulation protein DQuickGO ontologyBLASTP
173045317319041452UDP-N-acetylmuramoylalanyl-D-glutamate--2 6-diaminopimelate ligaseQuickGO ontologyBLASTP