Pre_GI Gene

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Host: NC_012563 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012563:1464000 Clostridium botulinum A2 str. Kyoto, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14644721464729258hypothetical proteinBLASTP
14650121465758747putative lipoproteinQuickGO ontologyBLASTP
14660771466304228glutaredoxin-like protein YruB-familyQuickGO ontologyBLASTP
146633614677961461putative glyceraldehyde-3-phosphate dehydrogenase NADP-dependentQuickGO ontologyBLASTP
14678361468777942putative thioredoxin reductaseQuickGO ontologyBLASTP
14695621469939378GrdX proteinQuickGO ontologyBLASTP
147003014713161287glycine reductase subunits ABCQuickGO ontologyBLASTP
147134914726501302glycine reductase selenoprotein BQuickGO ontologyBLASTP
14728011473742942thioredoxin-disulfide reductaseQuickGO ontologyBLASTP
14737761474096321thioredoxin family proteinQuickGO ontologyBLASTP
14741821474313132glycine reductase complex component A selenocysteine-containingQuickGO ontologyBLASTP
14743291474658330glycine reductase complex component A selenocysteine-containingQuickGO ontologyBLASTP
147475314762911539glycine reductase complex component C beta subunitQuickGO ontologyBLASTP
147630714774731167glycine reductase complex component C alpha subunitQuickGO ontologyBLASTP
14779001478511612DNA-3-methyladenine glycosylaseQuickGO ontologyBLASTP
147857714808022226restriction endonuclease family proteinQuickGO ontologyBLASTP
148123914824501212S-methyl-5-thioribose kinaseQuickGO ontologyBLASTP
148259014836391050S-methyl-5-thioribose-1-phosphate isomeraseQuickGO ontologyBLASTP
14836631483773111hypothetical proteinBLASTP
14837901484437648aldolase class II AraDFucA subfamilyQuickGO ontologyBLASTP
14846111485405795transcriptional regulator DeoR familyQuickGO ontologyBLASTP
14857141486073360hypothetical proteinBLASTP