Pre_GI Gene

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Host: NC_012472 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012472:4630485 Bacillus cereus 03BB102, complete genome

Host Lineage: Bacillus cereus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: Bacillus cereus 03BB102 was cultured from the blood of a 39 year old San Antonio, Texas welder who died as a result of a severe pneumonia thought to be caused by this microbe. Unlike B. anthracis, the isolate is hemolytic, motile and resistant to gamma phage. However, it is positive for a DFA-based cell wall test for B. anthracis, and it has all or most of the pXO1 pathogenicity island sequences including the sequences for pag, cya and lef. This organism is a soil-dwelling opportunistic pathogen that causes food poisoning in infected individuals. The rapid onset is characterized by nausea and vomiting while the late onset is characterized by diarrhea and abdominal pain. The emetic disease is caused by a small stable dodecadepsipeptide cerulide whereas the diarrheal disease is caused by a heat labile enterotoxin. Some strains produce a potent cytotoxin that forms a pore in the membrane of eukaryotic cells and causes necrotic enteritis (death of intestinal epithelial cells) while the unique tripartite membrane lytic toxin hemolysin BL contributes to the diarrheal disease and destructive infections of the eye.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
46297364630488753ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
463048546324581974hypothetical proteinBLASTP
46325124632703192hypothetical protein
463287246341971326gluconate permeaseQuickGO ontologyBLASTP
46343984635123726transcriptional regulator GntR familyQuickGO ontologyBLASTP
463512346361391017carbohydrate kinase PfkB familyQuickGO ontologyBLASTP
46361324636887756hypothetical proteinBLASTP
463688946379921104putative pyridoxal phosphate-dependent enzymeQuickGO ontologyBLASTP
463797046390701101hypothetical proteinBLASTP
46394344640294861D-alanyl-D-alanine carboxypeptidase family proteinQuickGO ontologyBLASTP
464037746414501074sensor histidine kinaseQuickGO ontologyBLASTP
46414764642174699DNA-binding response regulatorQuickGO ontologyBLASTP
464257646436821107N-acylamino acid racemaseQuickGO ontologyBLASTP
464368346451311449AMP-binding proteinQuickGO ontologyBLASTP
46454524646270819naphthoate synthaseQuickGO ontologyBLASTP
46463404647152813hydrolase alphabeta fold familyQuickGO ontologyBLASTP
4647149464890317552-succinyl-6-hydroxy-2 4-cyclohexadiene-1-carboxylic acid synthase2-oxoglutarate decarboxylaseQuickGO ontologyBLASTP
464890046502941395menaquinone-specific isochorismate synthaseQuickGO ontologyBLASTP
46504894651442954putative 14-dihydroxy-2-naphthoate octaprenyltransferaseQuickGO ontologyBLASTP
46515524652283732DNA binding protein DksATraR familyQuickGO ontologyBLASTP