Pre_GI Gene

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Host: NC_012472 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012472:2240000 Bacillus cereus 03BB102, complete genome

Host Lineage: Bacillus cereus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: Bacillus cereus 03BB102 was cultured from the blood of a 39 year old San Antonio, Texas welder who died as a result of a severe pneumonia thought to be caused by this microbe. Unlike B. anthracis, the isolate is hemolytic, motile and resistant to gamma phage. However, it is positive for a DFA-based cell wall test for B. anthracis, and it has all or most of the pXO1 pathogenicity island sequences including the sequences for pag, cya and lef. This organism is a soil-dwelling opportunistic pathogen that causes food poisoning in infected individuals. The rapid onset is characterized by nausea and vomiting while the late onset is characterized by diarrhea and abdominal pain. The emetic disease is caused by a small stable dodecadepsipeptide cerulide whereas the diarrheal disease is caused by a heat labile enterotoxin. Some strains produce a potent cytotoxin that forms a pore in the membrane of eukaryotic cells and causes necrotic enteritis (death of intestinal epithelial cells) while the unique tripartite membrane lytic toxin hemolysin BL contributes to the diarrheal disease and destructive infections of the eye.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
22402152240427213hypothetical proteinBLASTP
224117122436752505penicillin-binding protein 1AQuickGO ontologyBLASTP
22442912244701411major facilitator family transporterQuickGO ontologyBLASTP
22446922245426735major facilitator family transporterQuickGO ontologyBLASTP
22454422245732291hypothetical proteinBLASTP
224613122472521122citrate Si-synthase MmgDQuickGO ontologyBLASTP
224735122487871437mmgE proteinQuickGO ontologyBLASTP
22488062249714909methylisocitrate lyaseQuickGO ontologyBLASTP
22497242249840117hypothetical proteinBLASTP
224986922515781710acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
22515952252485891putative 2-hydroxy-3-oxopropionate reductaseQuickGO ontologyBLASTP
225252222539821461methylmalonic acid semialdehyde dehydrogenaseQuickGO ontologyBLASTP
22540532254685633putative homoserinethreonine efflux proteinQuickGO ontologyBLASTP
225485922559141056enoyl-CoA hydrataseisomerase family proteinQuickGO ontologyBLASTP
22562302256487258hypothetical proteinBLASTP
22566712256910240hypothetical proteinBLASTP
225692622580831158putative exonuclease SbcDQuickGO ontologyBLASTP
225808022611693090putative exonucleaseQuickGO ontologyBLASTP
22612842261457174hypothetical proteinBLASTP
22617872262086300transcriptional regulator ArsR familyQuickGO ontologyBLASTP