Pre_GI Gene

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Host: NC_012472 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_012472:1339500 Bacillus cereus 03BB102, complete genome

Host Lineage: Bacillus cereus; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: Bacillus cereus 03BB102 was cultured from the blood of a 39 year old San Antonio, Texas welder who died as a result of a severe pneumonia thought to be caused by this microbe. Unlike B. anthracis, the isolate is hemolytic, motile and resistant to gamma phage. However, it is positive for a DFA-based cell wall test for B. anthracis, and it has all or most of the pXO1 pathogenicity island sequences including the sequences for pag, cya and lef. This organism is a soil-dwelling opportunistic pathogen that causes food poisoning in infected individuals. The rapid onset is characterized by nausea and vomiting while the late onset is characterized by diarrhea and abdominal pain. The emetic disease is caused by a small stable dodecadepsipeptide cerulide whereas the diarrheal disease is caused by a heat labile enterotoxin. Some strains produce a potent cytotoxin that forms a pore in the membrane of eukaryotic cells and causes necrotic enteritis (death of intestinal epithelial cells) while the unique tripartite membrane lytic toxin hemolysin BL contributes to the diarrheal disease and destructive infections of the eye.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13395281339893366hypothetical proteinBLASTP
13401131340580468hypothetical proteinBLASTP
13406651340778114hypothetical proteinBLASTP
13411311341370240hypothetical proteinBLASTP
13414971341736240hypothetical proteinBLASTP
13417961342011216hypothetical proteinBLASTP
13421531343049897branched-chain amino acid aminotransferaseQuickGO ontologyBLASTP
134335713450661710acetolactate synthase large subunit biosynthetic typeQuickGO ontologyBLASTP
13450631345572510acetolactate synthase small subunitQuickGO ontologyBLASTP
134559913466091011ketol-acid reductoisomeraseQuickGO ontologyBLASTP
1346611134813115212-isopropylmalate synthaseQuickGO ontologyBLASTP
1348209134927310653-isopropylmalate dehydrogenaseQuickGO ontologyBLASTP
1349273135066713953-isopropylmalate dehydratase large subunitQuickGO ontologyBLASTP
135064513512265823-isopropylmalate dehydratase small subunitQuickGO ontologyBLASTP
135153713527991263ATP phosphoribosyltransferase regulatory subunitQuickGO ontologyBLASTP
13527751353410636ATP phosphoribosyltransferaseQuickGO ontologyBLASTP
135342213547111290histidinol dehydrogenaseQuickGO ontologyBLASTP
13547111355295585imidazoleglycerol-phosphate dehydrataseQuickGO ontologyBLASTP
13552961355925630imidazole glycerol phosphate synthase glutamine amidotransferaseQuickGO ontologyBLASTP
135589813566177201-5-phosphoribosyl-5-5- phosphoribosylaminomethylideneaminoimidazole-4- carboxamide isomeraseQuickGO ontologyBLASTP
13566111357369759imidazoleglycerol phosphate synthase cyclase subunitQuickGO ontologyBLASTP
13573661357671306phosphoribosyl-ATP pyrophosphataseQuickGO ontologyBLASTP