Pre_GI Gene

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Host: NC_011896 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011896:563641 Mycobacterium leprae Br4923, complete genome

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
563641564546906putative secreted proteinQuickGO ontologyBLASTP
564592565236645hypothetical proteinBLASTP
566066566848783hypothetical proteinBLASTP
571612571902291hypothetical proteinBLASTP
574041574283243hypothetical proteinBLASTP
574547574819273hypothetical proteinBLASTP
575478576149672hypothetical proteinBLASTP
576370577125756hypothetical proteinBLASTP
581233581799567crossover junction endodeoxyribonucleaseQuickGO ontologyBLASTP
581796582407612Holliday junction DNA helicase componentQuickGO ontologyBLASTP
5824045834531050Holliday junction helicase componentQuickGO ontologyBLASTP