Pre_GI Gene

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Host: NC_011896 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011896:363448 Mycobacterium leprae Br4923, complete genome

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
363448364137690hypothetical proteinBLASTP
364932365738807putative cation-efflux transporter componentQuickGO ontologyBLASTP
365876366289414hypothetical proteinBLASTP
366401367279879hypothetical proteinBLASTP
3672953683321038putative fructose bisphosphate aldolaseQuickGO ontologyBLASTP
368465369133669hypothetical proteinBLASTP
372050372442393hypothetical proteinBLASTP
373621373860240hypothetical proteinBLASTP
375469375678210hypothetical proteinBLASTP
3775033791461644putative thiamine biosynthesis proteinQuickGO ontologyBLASTP
379143379982840putative phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
380661381446786putative thiamine biosynthesis proteinQuickGO ontologyBLASTP
381439381663225hypothetical proteinBLASTP
3816713826931023putative oxidoreductaseQuickGO ontologyBLASTP
382851383558708putative thiamine-phosphate pyrophosphorylaseQuickGO ontologyBLASTP
385666386646981putative glutamine-binding proteinQuickGO ontologyBLASTP
3866463889492304putative serine-threonine protein kinaseQuickGO ontologyBLASTP