Pre_GI Gene

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Host: NC_011896 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011896:3204579 Mycobacterium leprae Br4923, complete genome

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
320457932094084830putative cation transport ATPaseQuickGO ontologyBLASTP
321051632127562241isocitrate dehydrogenaseQuickGO ontologyBLASTP
32215643222274711putative TetR-family transcriptional regulatorQuickGO ontologyBLASTP
322227132252733003hypothetical proteinBLASTP
322527032279512682hypothetical proteinBLASTP
323018332319971815replicative DNA helicaseQuickGO ontologyBLASTP