Pre_GI Gene

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Host: NC_011896 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011896:1 Mycobacterium leprae Br4923, complete genome

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
115661566putative chromosomal replication initiator proteinQuickGO ontologyBLASTP
208132801200putative DNA polymerase III beta subunitQuickGO ontologyBLASTP
328144381158putative DNA replication and SOS induction proteinQuickGO ontologyBLASTP
44355004570hypothetical proteinBLASTP
522972652037putative DNA gyrase subunit BQuickGO ontologyBLASTP
7318110673750putative DNA gyrase subunit AQuickGO ontologyBLASTP
1119512106912hypothetical proteinBLASTP
124041247976tRNA-AlaQuickGO ontologyBLASTP
1285613230375hypothetical proteinBLASTP
1377513966192hypothetical proteinBLASTP
1598916537549putative peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
1656216975414hypothetical proteinBLASTP
1713017411282hypothetical proteinBLASTP
1832119019699putative p-aminobenzoate synthase glutamine amidotransferaseQuickGO ontologyBLASTP
18997208651869putative serinethreonine protein kinaseQuickGO ontologyBLASTP