Pre_GI Gene

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Host: NC_011528 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011528:647401 Coxiella burnetii CbuK_Q154, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
647401648396996NAD dependent epimerasedehydratase familyQuickGO ontologyBLASTP
6483936495471155perosamine synthetaseQuickGO ontologyBLASTP
6495506514481899asparagine synthetase glutamine-hydrolyzingQuickGO ontologyBLASTP
651449652000552bacterial transferase family hexapeptide motifQuickGO ontologyBLASTP
6520116538161806phospholipid-lipopolysaccharide ABC transporterQuickGO ontologyBLASTP
653829654815987methyltransferaseQuickGO ontologyBLASTP
654824655093270hypothetical proteinBLASTP
6550976561731077radical SAM superfamily proteinQuickGO ontologyBLASTP
6561886576721485hypothetical membrane spanning proteinQuickGO ontologyBLASTP
6579596590591101lipopolysaccharide N-acetylglucosaminyltransferaseQuickGO ontologyBLASTP
6591956604871293glycosyltransferaseQuickGO ontologyBLASTP
6604876624001914asparagine synthetase family proteinQuickGO ontologyBLASTP
6624076635401134alpha-D-QuiNAc alpha-13-galactosyltransferaseQuickGO ontologyBLASTP
6637716648681098UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
6648796660361158glycosyltransferaseQuickGO ontologyBLASTP
6660416670601020UDP-N-acetylglucosamine 4-epimeraseQuickGO ontologyBLASTP
6670486683371290UDP-N-acetyl-D-galactosamine 6-dehydrogenaseQuickGO ontologyBLASTP
6683956697441350UDP-glucose 6-dehydrogenaseQuickGO ontologyBLASTP