Pre_GI Gene

Some Help

Host: NC_011528 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011528:535680 Coxiella burnetii CbuK_Q154, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
535166535690525NADH-quinone oxidoreductase chain EQuickGO ontologyBLASTP
5356805369481269NADH-quinone oxidoreductase chain FQuickGO ontologyBLASTP
536929537048120hypothetical proteinBLASTP
5370595394222364NADH-quinone oxidoreductase chain GQuickGO ontologyBLASTP
5394225404441023NADH-quinone oxidoreductase chain HQuickGO ontologyBLASTP
540426540932507NADH-quinone oxidoreductase chain IQuickGO ontologyBLASTP
540946541551606NADH-quinone oxidoreductase chain JQuickGO ontologyBLASTP
541548541853306NADH-quinone oxidoreductase chain KQuickGO ontologyBLASTP
5419105438711962NADH-quinone oxidoreductase chain LQuickGO ontologyBLASTP
5438765453961521NADH-quinone oxidoreductase chain MQuickGO ontologyBLASTP
5454065468541449NADH-quinone oxidoreductase chain NQuickGO ontologyBLASTP
547248547709462hypothetical cytosolic proteinQuickGO ontologyBLASTP
5477135492241512N utilization substance protein AQuickGO ontologyBLASTP
5492305516412412bacterial protein translation initiation factor 2QuickGO ontologyBLASTP
551729552088360ribosome-binding factor AQuickGO ontologyBLASTP
552066552995930tRNA pseudouridine synthase BQuickGO ontologyBLASTP
553071553340270hypothetical proteinBLASTP
553487553804318hypothetical proteinBLASTP
5538015548951095transposaseQuickGO ontologyBLASTP