Pre_GI Gene

Some Help

Host: NC_011528 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011528:386417 Coxiella burnetii CbuK_Q154, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3864173905504134DNA-directed RNA polymerase beta chainQuickGO ontologyBLASTP
3908193950634245DNA-directed RNA polymerase beta chainQuickGO ontologyBLASTP
395204395521318hypothetical proteinBLASTP
3955183966121095transposaseQuickGO ontologyBLASTP
396732397154423SSU ribosomal protein S12PQuickGO ontologyBLASTP
397167397742576SSU ribosomal protein S7PQuickGO ontologyBLASTP
3977523998512100protein translation elongation factor GQuickGO ontologyBLASTP
3998674010601194protein translation elongation factor TuQuickGO ontologyBLASTP
401241401582342SSU ribosomal protein S10PQuickGO ontologyBLASTP
401604402257654LSU ribosomal protein L3PQuickGO ontologyBLASTP
402254402874621LSU ribosomal protein L1E L4PQuickGO ontologyBLASTP
402871403158288LSU ribosomal protein L23PQuickGO ontologyBLASTP
403178404005828LSU ribosomal protein L2PQuickGO ontologyBLASTP
404018404305288SSU ribosomal protein S19PQuickGO ontologyBLASTP
404305404652348LSU ribosomal protein L22PQuickGO ontologyBLASTP
404652405335684SSU ribosomal protein S3PQuickGO ontologyBLASTP
405347405760414LSU ribosomal protein L16PQuickGO ontologyBLASTP
405761405958198LSU ribosomal protein L29PQuickGO ontologyBLASTP
405969406220252SSU ribosomal protein S17PQuickGO ontologyBLASTP
406231406599369LSU ribosomal protein L14PQuickGO ontologyBLASTP
406611406934324LSU ribosomal protein L24PQuickGO ontologyBLASTP
407051407599549LSU ribosomal protein L5PQuickGO ontologyBLASTP
407604407903300SSU ribosomal protein S14PQuickGO ontologyBLASTP
407897408298402SSU ribosomal protein S8PQuickGO ontologyBLASTP