Pre_GI Gene

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Host: NC_011528 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011528:1769349 Coxiella burnetii CbuK_Q154, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17702771770762486hypothetical proteinBLASTP
17707591771664906ribosomal protein S6 modification proteinQuickGO ontologyBLASTP
177166717726951029succinylglutamate desuccinylaseaspartoacylase family proteinQuickGO ontologyBLASTP
177285017749462097mechanosensitive ion channelQuickGO ontologyBLASTP
17753461775744399hypothetical proteinBLASTP
1778939177903496hypothetical proteinBLASTP
17791381779293156hypothetical proteinBLASTP
17793261779604279hypothetical proteinBLASTP
17811081781242135hypothetical protein
17814011781724324hypothetical proteinBLASTP
17825501782687138hypothetical proteinBLASTP
178270217857133012IcmBQuickGO ontologyBLASTP
17857861786424639IcmJQuickGO ontologyBLASTP
17864371786862426IcmDQuickGO ontologyBLASTP
17869471787456510IcmCQuickGO ontologyBLASTP
17875271788261735IcmGQuickGO ontologyBLASTP
178827917913983120IcmEQuickGO ontologyBLASTP
179138517924401056IcmKQuickGO ontologyBLASTP