Pre_GI Gene

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Host: NC_011528 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011528:1492000 Coxiella burnetii CbuK_Q154, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14920031492740738hypothetical protein
14927571493092336hypothetical protein
14938411494617777polysaccharide export ATP-binding proteinQuickGO ontologyBLASTP
14946271495490864O-antigen export system permease proteinQuickGO ontologyBLASTP
149550014962497503-oxoacyl-acyl-carrier protein reductaseQuickGO ontologyBLASTP
14963861497219834325-bisphosphate nucleotidaseQuickGO ontologyBLASTP
149720114989581758sulfate adenylyltransferaseQuickGO ontologyBLASTP
149899415005531560sulfotransferaseQuickGO ontologyBLASTP
150075615019251170hypothetical proteinBLASTP
150194815031081161dTDP-4-dehydro-6-deoxy-D-glucose 4-aminotransferaseQuickGO ontologyBLASTP
150313915042931155nucleotide-sugar aminotransferaseQuickGO ontologyBLASTP
150428615056621377hypothetical proteinBLASTP
150575215068341083glycosyltransferaseQuickGO ontologyBLASTP
150696115080101050pyruvate dehydrogenase E1 component alpha subunitQuickGO ontologyBLASTP
150800715090681062pyruvate dehydrogenase E1 component beta subunitQuickGO ontologyBLASTP
150908915103271239methyltransferaseQuickGO ontologyBLASTP
15103201511177858polyprenyl-phosphate beta-D-mannosyltransferaseQuickGO ontologyBLASTP
151118615122321047GDP-mannose 46 dehydrataseQuickGO ontologyBLASTP
15122251513223999GDP-L-fucose synthaseQuickGO ontologyBLASTP
151360315152461644hypothetical exported membrane spanning proteinQuickGO ontologyBLASTP
151620115195243324hypothetical proteinBLASTP