Pre_GI Gene

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Host: NC_011528 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011528:1282691 Coxiella burnetii CbuK_Q154, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
128125012827041455chlorohydrolasedeaminase family proteinQuickGO ontologyBLASTP
12826911283590900hydroxymethylglutaryl-CoA lyaseQuickGO ontologyBLASTP
12836201284228609DedA family proteinQuickGO ontologyBLASTP
128428812863062019excinuclease ABC subunit BQuickGO ontologyBLASTP
128630012875711272aspartate aminotransferaseQuickGO ontologyBLASTP
1287626128770176tRNA-AsnQuickGO ontologyBLASTP
12941681294749582non-ribosomal peptide synthetase moduleQuickGO ontologyBLASTP
12948541295150297hypothetical proteinBLASTP
12965011296605105hypothetical proteinBLASTP
12967651296866102hypothetical proteinBLASTP
12968591297041183hypothetical proteinBLASTP
12972951297396102hypothetical proteinBLASTP
129757812991701593ankyrin repeat proteinQuickGO ontologyBLASTP
1299370129946293hypothetical proteinBLASTP
12994951299857363glyoxalase family proteinQuickGO ontologyBLASTP
12999381300054117hypothetical proteinBLASTP
13001311300838708ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
130083813020101173hypothetical proteinBLASTP
13020071302144138metal-dependent amidaseaminoacylasecarboxypeptidaseQuickGO ontologyBLASTP
13024861302842357hypothetical protein
13030221303138117hypothetical protein