Pre_GI Gene

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Host: NC_011527 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011527:953442 Coxiella burnetii CbuG_Q212, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii G Q212 was isolated from a case of endocarditis and does not carry a plasmid. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
9558659572561392ATPaseQuickGO ontologyBLASTP
960202960507306hypothetical proteinBLASTP
960513961460948quinone oxidoreductaseQuickGO ontologyBLASTP
962254962553300nucleotidyltransferaseQuickGO ontologyBLASTP
963147963311165hypothetical proteinBLASTP
964225964629405hypothetical protein
964694964888195hypothetical membrane-associated proteinQuickGO ontologyBLASTP
965048965428381hypothetical proteinBLASTP
96564196571171tRNA-CysQuickGO ontology
969917970147231hypothetical proteinBLASTP
9704529717801329adenosylmethionine-8-amino-7-oxononanoate aminotransferaseQuickGO ontologyBLASTP
972155973120966biotin synthaseQuickGO ontologyBLASTP
97310797426111558-amino-7-oxononanoate synthaseQuickGO ontologyBLASTP
974255974959705carboxylesteraseQuickGO ontologyBLASTP
974949975695747biotin synthesis proteinQuickGO ontologyBLASTP
975692976420729dethiobiotin synthetaseQuickGO ontologyBLASTP
976348977319972biotin operon repressorQuickGO ontologyBLASTP