Pre_GI Gene

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Host: NC_011527 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011527:525759 Coxiella burnetii CbuG_Q212, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii G Q212 was isolated from a case of endocarditis and does not carry a plasmid. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
525759526121363NADH-quinone oxidoreductase chain AQuickGO ontologyBLASTP
526126526611486NADH-quinone oxidoreductase chain BQuickGO ontologyBLASTP
526621527304684NADH-quinone oxidoreductase chain CQuickGO ontologyBLASTP
5272975285501254NADH-quinone oxidoreductase chain DQuickGO ontologyBLASTP
528550529074525NADH-quinone oxidoreductase chain EQuickGO ontologyBLASTP
5290645303321269NADH-quinone oxidoreductase chain FQuickGO ontologyBLASTP
5304435328062364NADH-quinone oxidoreductase chain GQuickGO ontologyBLASTP
5328065338281023NADH-quinone oxidoreductase chain HQuickGO ontologyBLASTP
533810534316507NADH-quinone oxidoreductase chain IQuickGO ontologyBLASTP
534330534935606NADH-quinone oxidoreductase chain JQuickGO ontologyBLASTP
534932535237306NADH-quinone oxidoreductase chain KQuickGO ontologyBLASTP
5352945372551962NADH-quinone oxidoreductase chain LQuickGO ontologyBLASTP
5372605387801521NADH-quinone oxidoreductase chain MQuickGO ontologyBLASTP
5387905402381449NADH-quinone oxidoreductase chain NQuickGO ontologyBLASTP
540611541072462hypothetical cytosolic proteinQuickGO ontologyBLASTP
5410765425871512N utilization substance protein AQuickGO ontologyBLASTP
5425935450042412bacterial protein translation initiation factor 2QuickGO ontologyBLASTP
545092545451360ribosome-binding factor AQuickGO ontologyBLASTP
545429546358930tRNA pseudouridine synthase BQuickGO ontologyBLASTP
546528546740213hypothetical proteinBLASTP
546834547169336hypothetical proteinBLASTP
5471665482601095transposaseQuickGO ontologyBLASTP