Pre_GI Gene

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Host: NC_011527 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011527:1688447 Coxiella burnetii CbuG_Q212, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii G Q212 was isolated from a case of endocarditis and does not carry a plasmid. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
16884471688878432LSU ribosomal protein L15PQuickGO ontologyBLASTP
16888811689072192LSU ribosomal protein L30PQuickGO ontologyBLASTP
16890761689582507SSU ribosomal protein S5PQuickGO ontologyBLASTP
16895941689947354LSU ribosomal protein L18PQuickGO ontologyBLASTP
16899471690483537LSU ribosomal protein L6PQuickGO ontologyBLASTP
16905211690922402SSU ribosomal protein S8PQuickGO ontologyBLASTP
16909161691215300SSU ribosomal protein S14PQuickGO ontologyBLASTP
16912201691768549LSU ribosomal protein L5PQuickGO ontologyBLASTP
16918841692207324LSU ribosomal protein L24PQuickGO ontologyBLASTP
16922191692587369LSU ribosomal protein L14PQuickGO ontologyBLASTP
16925981692849252SSU ribosomal protein S17PQuickGO ontologyBLASTP
16928601693057198LSU ribosomal protein L29PQuickGO ontologyBLASTP
16930581693471414LSU ribosomal protein L16PQuickGO ontologyBLASTP
16934831694166684SSU ribosomal protein S3PQuickGO ontologyBLASTP
16941661694513348LSU ribosomal protein L22PQuickGO ontologyBLASTP
16945131694800288SSU ribosomal protein S19PQuickGO ontologyBLASTP
16948131695640828LSU ribosomal protein L2PQuickGO ontologyBLASTP
16956601695947288LSU ribosomal protein L23PQuickGO ontologyBLASTP
16959441696564621LSU ribosomal protein L1E L4PQuickGO ontologyBLASTP
16965611697214654LSU ribosomal protein L3PQuickGO ontologyBLASTP
16972361697577342SSU ribosomal protein S10PQuickGO ontologyBLASTP
169775816989511194protein translation elongation factor TuQuickGO ontologyBLASTP
169896717010662100protein translation elongation factor GQuickGO ontologyBLASTP
17010761701651576SSU ribosomal protein S7PQuickGO ontologyBLASTP
17016641702086423SSU ribosomal protein S12PQuickGO ontologyBLASTP
170238017066244245DNA-directed RNA polymerase beta chainQuickGO ontologyBLASTP
170689117110244134DNA-directed RNA polymerase beta chainQuickGO ontologyBLASTP