Pre_GI Gene

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Host: NC_011527 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011527:1113217 Coxiella burnetii CbuG_Q212, complete genome

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii G Q212 was isolated from a case of endocarditis and does not carry a plasmid. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
111321711145061290UDP-N-acetyl-D-galactosamine 6-dehydrogenaseQuickGO ontologyBLASTP
111449411155131020UDP-N-acetylglucosamine 4-epimeraseQuickGO ontologyBLASTP
111551811166751158glycosyltransferaseQuickGO ontologyBLASTP
111668611177831098UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
111801411191471134alpha-D-QuiNAc alpha-13-galactosyltransferaseQuickGO ontologyBLASTP
111915411210671914asparagine synthetase family proteinQuickGO ontologyBLASTP
112106711223591293glycosyltransferaseQuickGO ontologyBLASTP
112249511235951101lipopolysaccharide N-acetylglucosaminyltransferaseQuickGO ontologyBLASTP
112388211253661485hypothetical membrane spanning proteinQuickGO ontologyBLASTP
112538111264571077radical SAM superfamily proteinQuickGO ontologyBLASTP
11264611126730270hypothetical proteinBLASTP
11267391127725987methyltransferaseQuickGO ontologyBLASTP
112773811295431806phospholipid-lipopolysaccharide ABC transporterQuickGO ontologyBLASTP
11295541130105552bacterial transferase family hexapeptide motifQuickGO ontologyBLASTP
113010611320041899asparagine synthetase glutamine-hydrolyzingQuickGO ontologyBLASTP