Pre_GI Gene

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Host: NC_011498 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011498:1571840 Helicobacter pylori P12, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
157184015730121173selenocysteine synthaseQuickGO ontologyBLASTP
157310915742961188transcription termination factor AQuickGO ontologyBLASTP
15743531574847495hypothetical proteinBLASTP
157582015797283909type IIS R-M system restrictionmodification enzymeQuickGO ontologyBLASTP
158002015820232004hypothetical proteinBLASTP
158215715850662910type III R-M system restriction enzymeQuickGO ontologyBLASTP
158506915871112043type III R-M system methyltransferaseQuickGO ontologyBLASTP
158716015890311872ATP-dependent DNA helicase RecGQuickGO ontologyBLASTP
15891131589460348hypothetical proteinBLASTP
15894641590099636hypothetical proteinBLASTP
15900961590848753exodeoxyribonucleaseQuickGO ontologyBLASTP