Pre_GI Gene

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Host: NC_011498 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011498:1391788 Helicobacter pylori P12, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13948331395621789hypothetical proteinBLASTP
13956241395854231hypothetical proteinBLASTP
13958471396335489hypothetical proteinBLASTP
13963231396607285VirB2 type IV secretion proteinQuickGO ontologyBLASTP
13966191396882264VirB3 type IV secretion proteinQuickGO ontologyBLASTP
13968941397130237hypothetical proteinBLASTP
139713013997062577VirB4 type IV secretion ATPaseQuickGO ontologyBLASTP
13997031399843141VirB7 type IV secretion proteinQuickGO ontologyBLASTP
139983614009721137VirB8 type IV secretion proteinQuickGO ontologyBLASTP
140096914026241656VirB9 type IV secretion proteinQuickGO ontologyBLASTP
140259114038291239VirB10 type IV secretion proteinQuickGO ontologyBLASTP
140381314055971785hypothetical proteinBLASTP
14055011406055555hypothetical proteinBLASTP
14060681407030963hypothetical proteinBLASTP
14070471407322276hypothetical proteinBLASTP
14073271408271945VirB11 type IV secretion ATPaseQuickGO ontologyBLASTP
14082681408786519hypothetical proteinBLASTP
140878314110262244VirD4 coupling proteinQuickGO ontologyBLASTP
14131631413633471hypothetical proteinBLASTP
14136031414406804hypothetical proteinBLASTP
14144801415145666hypothetical proteinBLASTP
14151231415401279hypothetical proteinBLASTP
14153341415765432hypothetical proteinBLASTP
14157501416160411hypothetical proteinBLASTP