Pre_GI Gene

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Host: NC_011498 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011498:1345623 Helicobacter pylori P12, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
13449731345635663nicotinamide mononucleotide transporterQuickGO ontologyBLASTP
13456231346237615hypothetical proteinBLASTP
1346874134722435150S ribosomal protein L17QuickGO ontologyBLASTP
134722413482581035DNA-directed RNA polymerase alpha subunitQuickGO ontologyBLASTP
1348270134889662730S ribosomal protein S4QuickGO ontologyBLASTP
1348906134930139630S ribosomal protein S11QuickGO ontologyBLASTP
1349324134968636330S ribosomal protein S13QuickGO ontologyBLASTP
13498821350100219translation initiation factor If-1QuickGO ontologyBLASTP
13501001350861762methionine aminopeptidaseQuickGO ontologyBLASTP
135086113521231263preprotein translocase SecY subunitQuickGO ontologyBLASTP
1352166135256740250S ribosomal protein L15QuickGO ontologyBLASTP
1352585135304646230S ribosomal protein S5QuickGO ontologyBLASTP
1353043135339935750S ribosomal protein L18QuickGO ontologyBLASTP
1353413135394953750S ribosomal protein L6QuickGO ontologyBLASTP
1353960135435539630S ribosomal protein S8QuickGO ontologyBLASTP
1354562135510754650S ribosomal protein L5QuickGO ontologyBLASTP
1355120135534122250S ribosomal protein L24QuickGO ontologyBLASTP
1355316135570839350S ribosomal protein L14QuickGO ontologyBLASTP
1355711135597126130S ribosomal protein S17QuickGO ontologyBLASTP
1355985135618520150S ribosomal protein L29QuickGO ontologyBLASTP
1356172135659742650S ribosomal protein L16QuickGO ontologyBLASTP
1356600135730470530S ribosomal protein S3QuickGO ontologyBLASTP
1357308135767636950S ribosomal protein L22QuickGO ontologyBLASTP
1357686135796728230S ribosomal protein S19QuickGO ontologyBLASTP
1357978135880883150S ribosomal protein L2QuickGO ontologyBLASTP
1358825135910628250S ribosomal protein L23QuickGO ontologyBLASTP
1359110135975764850S ribosomal protein L4QuickGO ontologyBLASTP
1359792136036757650S ribosomal protein L3QuickGO ontologyBLASTP
1360404136071831530S ribosomal protein S10QuickGO ontologyBLASTP
136092813620161089hypothetical proteinBLASTP
13622051362783579hypothetical proteinBLASTP
13627571363371615ribonuclease hIIQuickGO ontologyBLASTP
13634791363652174hypothetical proteinBLASTP
136367413650651392fumaraseQuickGO ontologyBLASTP
13652401365617378hypothetical proteinBLASTP
136562213668601239hypothetical proteinBLASTP
136685713678731017cobalt-zinc-cadmium resistance proteinQuickGO ontologyBLASTP
136787413709813108cobalt-zinc-cadmium resistance proteinQuickGO ontologyBLASTP
13709621371318357branched-chain amino acid transport proteinQuickGO ontologyBLASTP
13713121371998687branched-chain amino acid transport proteinQuickGO ontologyBLASTP