Pre_GI Gene

Some Help

Host: NC_011333 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011333:514464 Helicobacter pylori G27 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori is a gram-negative pathogen that colonizes the stomachs of over half the world's population. Originally isolated from an endoscopy patient from Grosseto Hospital (Tuscany, Italy). Causes peptic ulcers. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
514464514715252hypothetical proteinBLASTP
5147155161601446cag pathogenicity island protein 3QuickGO ontologyBLASTP
516165516674510cag pathogenicity island protein 4QuickGO ontologyBLASTP
5167935190392247cag pathogenicity island protein 5QuickGO ontologyBLASTP
519048520040993virB11-like cag pathogenicity islandencoded protein ATPaseQuickGO ontologyBLASTP
520045520644600cag pathogenicity island protein ZQuickGO ontologyBLASTP
5265065280711566cag pathogenicity island protein XQuickGO ontologyBLASTP
5281235297301608cag pathogenicity island protein WQuickGO ontologyBLASTP
529735530493759cag pathogenicity island protein VQuickGO ontologyBLASTP
530890531540651cag pathogenicity island protein UQuickGO ontologyBLASTP
531553532395843cag pathogenicity island protein TQuickGO ontologyBLASTP
532592533191600cag pathogenicity island protein SQuickGO ontologyBLASTP
535518535823306cag pathogenicity island protein QQuickGO ontologyBLASTP
535835536014180hypothetical proteinBLASTP
5371005382301131cag pathogenicity island protein MQuickGO ontologyBLASTP