Pre_GI Gene

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Host: NC_011333 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011333:1236730 Helicobacter pylori G27 chromosome, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori is a gram-negative pathogen that colonizes the stomachs of over half the world's population. Originally isolated from an endoscopy patient from Grosseto Hospital (Tuscany, Italy). Causes peptic ulcers. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
123673012378811152NaH antiporterQuickGO ontologyBLASTP
123790712392861380hypothetical proteinBLASTP
123945512406301176sugar efflux transporterQuickGO ontologyBLASTP
12409041241647744alpha-carbonic anhydraseQuickGO ontologyBLASTP
12418771242836960hypothetical proteinBLASTP
124311312443511239hypothetical proteinBLASTP
124462812457371110hypothetical proteinBLASTP
124601412471981185hypothetical proteinBLASTP
12476311248437807aspartate-semialdehyde dehydrogenaseQuickGO ontologyBLASTP
124865812499861329histidyl-tRNA synthetaseQuickGO ontologyBLASTP
125004812510971050ADP-heptose-LPS heptosyltransferase IIQuickGO ontologyBLASTP
12512861251720435hypothetical proteinBLASTP
12519381252927990aldo-ketoreductaseQuickGO ontologyBLASTP
125344312555212079elongation factor GQuickGO ontologyBLASTP
1255533125600046830S ribosomal protein S7QuickGO ontologyBLASTP
1256016125642340830S ribosomal protein S12QuickGO ontologyBLASTP
125651212649298418DNA-directed RNA polymerase subunit betaQuickGO ontologyBLASTP