Pre_GI Gene

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Host: NC_011264 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011264:11018 Borrelia duttonii Ly plasmid pl32, complete sequence

Host Lineage: Borrelia duttonii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: Borrelia duttonii Ly was isolated from a 2-year-old girl with tick-borne relapsing fever in Tanzania. Borrelia duttonii is the causative agent of tick-borne relapsing fever in east Africa. This disease is endemic in much of east Africa and is one of the top 10 diseases associated with deaths in children under the age of five. This disease is transmitted by the bite of the soft-bodied tick Ornithodoros moubata. Ticks become infected with Borrelia duttonii while feeding on an infected rodent. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Humans become exposed to the infected ticks through contact with rodents or rodent nests. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34888855antigen P35-like proteinQuickGO ontologyBLASTP
356246501089vlp protein alpha subfamilyQuickGO ontologyBLASTP
48375811975vlp protein delta subfamilyQuickGO ontologyBLASTP
1229112935645vsp proteinQuickGO ontologyBLASTP
13136141581023vlp protein delta subfamilyQuickGO ontologyBLASTP
1445915052594hypothetical proteinBLASTP
1544115611171hypothetical protein
1586516395531putative lipoproteinQuickGO ontologyBLASTP
1661317500888putative lipoproteinQuickGO ontology
1761517752138hypothetical protein
1970320302600PF49 plasmid partition proteinQuickGO ontologyBLASTP
2032521077753PF32 plasmid partition proteinQuickGO ontologyBLASTP
2105321655603plasmid partitioning associated protein-1QuickGO ontologyBLASTP
2163922316678hypothetical protein
23314246001287vlp protein beta subfamilyQuickGO ontologyBLASTP
2766528564900uncharacterized_conserved proteinQuickGO ontology
2949329735243hypothetical proteinBLASTP
3001730655639hypothetical proteinBLASTP
3072730990264hypothetical protein
3115031419270hypothetical protein