Pre_GI Gene

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Host: NC_011262 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011262:13649 Borrelia duttonii Ly plasmid pl31, complete sequence

Host Lineage: Borrelia duttonii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: Borrelia duttonii Ly was isolated from a 2-year-old girl with tick-borne relapsing fever in Tanzania. Borrelia duttonii is the causative agent of tick-borne relapsing fever in east Africa. This disease is endemic in much of east Africa and is one of the top 10 diseases associated with deaths in children under the age of five. This disease is transmitted by the bite of the soft-bodied tick Ornithodoros moubata. Ticks become infected with Borrelia duttonii while feeding on an infected rodent. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Humans become exposed to the infected ticks through contact with rodents or rodent nests. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
16512141050vlp protein delta subfamilyQuickGO ontologyBLASTP
41244774651ORFk-like protein lipoproteinQuickGO ontologyBLASTP
1364914533885hypothetical proteinBLASTP
1475415122369hypothetical proteinBLASTP
1796018658699ORFk-like protein lipoproteinQuickGO ontologyBLASTP
2075921397639bdr proteinQuickGO ontologyBLASTP
2201122619609vsp proteinQuickGO ontologyBLASTP
23140242641125vlp protein gamma subfamilyQuickGO ontologyBLASTP
2542226114693ORFk-like protein lipoproteinQuickGO ontologyBLASTP
2626926808540family 115-like proteinQuickGO ontologyBLASTP
2802128581561bdr proteinQuickGO ontologyBLASTP
29081301871107vlp protein gamma subfamilyQuickGO ontologyBLASTP