Pre_GI Gene

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Host: NC_011248 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011248:23500 Borrelia duttonii Ly plasmid pl35, complete sequence

Host Lineage: Borrelia duttonii; Borrelia; Spirochaetaceae; Spirochaetales; Spirochaetes; Bacteria

General Information: Borrelia duttonii Ly was isolated from a 2-year-old girl with tick-borne relapsing fever in Tanzania. Borrelia duttonii is the causative agent of tick-borne relapsing fever in east Africa. This disease is endemic in much of east Africa and is one of the top 10 diseases associated with deaths in children under the age of five. This disease is transmitted by the bite of the soft-bodied tick Ornithodoros moubata. Ticks become infected with Borrelia duttonii while feeding on an infected rodent. Borrelia then multiplies rapidly, causing a generalized infection throughout the tick. While feeding, the tick passes the organism into a mammalian host through its infectious saliva. Humans become exposed to the infected ticks through contact with rodents or rodent nests. Relapsing fever is characterized by a period of chills, fever, headache, and malaise, an asymptomatic period, followed by another episode of symptoms. This cycle of relapsing is due to changes in the surface proteins of Borrelia, which allow it to avoid detection and removal by the host immune system. This antigenic variation is the result of homologous recombination of silent proteins into an expressed locus, causing partial or complete replacement of one serotype with another.


StartEndLengthCDS descriptionQuickGO ontologyBLASTP
12242078855antigen P35-like proteinQuickGO ontologyBLASTP
25382792255BLASTP
31143941828vsp proteinQuickGO ontologyBLASTP
405052041155vlp protein beta subfamilyQuickGO ontologyBLASTP
539764251029vlp protein delta subfamilyQuickGO ontologyBLASTP
66097466858
775288191068vlp protein gamma subfamilyQuickGO ontologyBLASTP
9031100561026vlp protein delta subfamilyQuickGO ontologyBLASTP
10346114301085BLASTP
1117411431258BLASTP
1164512193549BLASTP
23528246041077vlp protein delta subfamilyQuickGO ontologyBLASTP
2479425744951vlp protein delta subfamilyQuickGO ontologyBLASTP
2609527036942vlp protein gamma subfamilyQuickGO ontologyBLASTP
2785128468618PF49 plasmid partition proteinQuickGO ontologyBLASTP
2847329237765PF32 plasmid partition proteinQuickGO ontologyBLASTP
2921329773561plasmid partitioning associated protein-1QuickGO ontologyBLASTP
2980230293492
3074031347608BLASTP
32234338681635hypothetical proteinBLASTP
3386534428564hypothetical protein
3450035099600bdr proteinQuickGO ontologyBLASTP