Pre_GI Gene

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Host: NC_011080 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011080:4543000 Salmonella enterica subsp. enterica serovar Newport str. SL254,

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: The SL254 strain is an MDR strain from one of two distinct lineages of the Newport serovar. Salmonella enterica subsp. enterica serovar Newport is common worldwide. Outbreak investigations and targeted studies have identified dairy cattle as the main reservoir this serotype. Antimicrobial resistance (Newport MDR-AmpC) is particularly problematic in this serotype, and the prevalence of Newport MDR-AmpC isolates from humans in the United States has increased from 0% during 1996-1997 to 26% in 2001. MDR strains have been recorded as resistant to ampicillin, chloramphenicol, streptomycin, sulphonamides and tetracycline (ACSSuT) and many of these strains show intermediate or full resistance to third-generation cephalosporins, kanamycin, potentiated sulphonamides, and gentamicin. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
454300045454292430anaerobic dimethyl sulfoxide reductase chain aQuickGO ontologyBLASTP
45454434546069627dimethylsulfoxide reductase chain BQuickGO ontologyBLASTP
45460624546835774dmso reductase anchor subunitQuickGO ontologyBLASTP
45469104547503594oxidoreductase componentQuickGO ontologyBLASTP
454758745489871401hypothetical proteinBLASTP
45490134549126114hypothetical proteinBLASTP
45492914550196906putative inner membrane proteinQuickGO ontologyBLASTP
45508574551039183hypothetical proteinBLASTP
45510324551304273putative GerE family regulatory proteinQuickGO ontologyBLASTP
45513164552191876AraC family regulatory proteinQuickGO ontologyBLASTP
45523284552453126hypothetical proteinBLASTP
45529944553287294hypothetical proteinBLASTP
45532844553775492acetyltransferase gnat familyQuickGO ontologyBLASTP
45539784554445468integrase catalytic regionQuickGO ontologyBLASTP
45553914555531141hypothetical protein
45555564555861306repressor proteinQuickGO ontologyBLASTP
45560634556893831periplasmic chaperoneQuickGO ontologyBLASTP
45598974560148252putative invasin proteinQuickGO ontologyBLASTP
45602274560355129hypothetical protein
45608654561332468hypothetical protein
45615134562172660thioldisulfide interchange protein DsbAQuickGO ontologyBLASTP
45625564562681126hypothetical protein
45628724563084213hypothetical proteinBLASTP
45633604563506147hypothetical protein
45635324564380849SrgBQuickGO ontologyBLASTP
45645254565277753putative acid phosphataseQuickGO ontologyBLASTP
45653204565454135ail and OmpX HomologQuickGO ontologyBLASTP
45661794566754576transcriptional regulator TetR familyQuickGO ontologyBLASTP
456679145684941704thioldisulfide interchange protein DsbDQuickGO ontologyBLASTP
45684704568817348divalent-cation tolerance protein CutAQuickGO ontologyBLASTP
456893845702391302anaerobic C4-dicarboxylate transporter DcuAQuickGO ontologyBLASTP
457035445717901437aspartate ammonia-lyaseQuickGO ontologyBLASTP