Pre_GI Gene

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Host: NC_011080 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011080:3941909 Salmonella enterica subsp. enterica serovar Newport str. SL254,

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: The SL254 strain is an MDR strain from one of two distinct lineages of the Newport serovar. Salmonella enterica subsp. enterica serovar Newport is common worldwide. Outbreak investigations and targeted studies have identified dairy cattle as the main reservoir this serotype. Antimicrobial resistance (Newport MDR-AmpC) is particularly problematic in this serotype, and the prevalence of Newport MDR-AmpC isolates from humans in the United States has increased from 0% during 1996-1997 to 26% in 2001. MDR strains have been recorded as resistant to ampicillin, chloramphenicol, streptomycin, sulphonamides and tetracycline (ACSSuT) and many of these strains show intermediate or full resistance to third-generation cephalosporins, kanamycin, potentiated sulphonamides, and gentamicin. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
394190939447072799sigma-54 dependent transcription regulatorQuickGO ontologyBLASTP
39449043945197294hypothetical proteinBLASTP
39451823945325144hypothetical proteinBLASTP
394530339466851383beta-glucosidaseQuickGO ontologyBLASTP
39481543948513360putative cytoplasmic proteinQuickGO ontologyBLASTP
39484973948820324DNA-binding proteinQuickGO ontologyBLASTP
39498123949925114hypothetical proteinBLASTP
39501353950404270phosphotransferase system HPr enzymeQuickGO ontologyBLASTP
39504143951274861fructose-16-bisphosphate aldolase class IIQuickGO ontologyBLASTP
395133739528211485carbohydrate kinase FGGY family proteinQuickGO ontologyBLASTP
395281439541721359PTS system galactitol-specific IIC componentQuickGO ontologyBLASTP
39542483954535288putative IIB component of PTS systemQuickGO ontologyBLASTP
39545323955005474putative phosphotransferase system mannitolfructose-specific IIA domainQuickGO ontologyBLASTP
39550233955766744putative GntR-family transcriptional regulatorQuickGO ontologyBLASTP
39561193956571453hypothetical proteinBLASTP
395676439581551392hexose phosphate transport proteinQuickGO ontologyBLASTP
395829839596261329regulatory protein UhpCQuickGO ontologyBLASTP
395963639611381503sensor protein UhpBQuickGO ontologyBLASTP
39611383961728591transcriptional regulatory protein UhpAQuickGO ontologyBLASTP
396180339628161014DeoXQuickGO ontologyBLASTP
396282839641441317L-fucoseH symporter permeaseQuickGO ontologyBLASTP