Pre_GI Gene

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Host: NC_011080 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_011080:1470794 Salmonella enterica subsp. enterica serovar Newport str. SL254,

Host Lineage: Salmonella enterica; Salmonella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: The SL254 strain is an MDR strain from one of two distinct lineages of the Newport serovar. Salmonella enterica subsp. enterica serovar Newport is common worldwide. Outbreak investigations and targeted studies have identified dairy cattle as the main reservoir this serotype. Antimicrobial resistance (Newport MDR-AmpC) is particularly problematic in this serotype, and the prevalence of Newport MDR-AmpC isolates from humans in the United States has increased from 0% during 1996-1997 to 26% in 2001. MDR strains have been recorded as resistant to ampicillin, chloramphenicol, streptomycin, sulphonamides and tetracycline (ACSSuT) and many of these strains show intermediate or full resistance to third-generation cephalosporins, kanamycin, potentiated sulphonamides, and gentamicin. This group of Enterobactericiae have pathogenic characteristics and are one of the most common causes of enteric infections (food poisoning) worldwide. They were named after the scientist Dr. Daniel Salmon who isolated the first organism, Salmonella choleraesuis, from the intestine of a pig. The presence of several pathogenicity islands (PAIs) that encode various virulence factors allows Salmonella spp. to colonize and infect host organisms. There are two important PAIs, Salmonella pathogenicity island 1 and 2 (SPI-1 and SPI-2) that encode two different type III secretion systems for the delivery of effector molecules into the host cell that result in internalization of the bacteria which then leads to systemic spread.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
147079414725421749sensor-kinaseQuickGO ontologyBLASTP
14724991473137639response regulatorQuickGO ontologyBLASTP
14732351473447213hypothetical proteinBLASTP
14735691474528960putative inner membrane proteinQuickGO ontologyBLASTP
14747011475429729transcriptional regulator MerR family proteinQuickGO ontologyBLASTP
14756081476246639EsrBQuickGO ontologyBLASTP
147627714790392763secretion system regulatorSensor componentQuickGO ontologyBLASTP
147984314813361494type III secretion outer membrane pore YscCHrcC familyQuickGO ontologyBLASTP
148132914825281200type III secretion apparatus protein YscDHrpQ familyQuickGO ontologyBLASTP
14825451482778234type III secretion system protein YseE familyQuickGO ontologyBLASTP
14833741483964591secretion system effector SseBQuickGO ontologyBLASTP
14839191484434516type III secretion low calcium response chaperone LcrHSycDQuickGO ontologyBLASTP
148443714858911455translocation machinery componentQuickGO ontologyBLASTP
14859911486494504translocation machinery componentQuickGO ontologyBLASTP
14864971486913417secreted effector proteinQuickGO ontologyBLASTP
14869651487399435type III secretion low calcium response chaperone LcrHSycDQuickGO ontologyBLASTP
14874151488197783secreted effector proteinQuickGO ontologyBLASTP
14881941488883690secreted effector proteinQuickGO ontologyBLASTP
14889771489192216type III secretion apparatus needle proteinQuickGO ontologyBLASTP
14891701489460291type III secretion system protein SsaH familyQuickGO ontologyBLASTP
14894571489720264type III secretion system apparatus proteinQuickGO ontologyBLASTP
14897171490466750type III secretion apparatus lipoprotein YscJHrcJ familyQuickGO ontologyBLASTP
14904841491032549putative cytoplasmic proteinQuickGO ontologyBLASTP
14910291491703675type III secretion apparatus protein HrpEYscL familyQuickGO ontologyBLASTP
14916931492685993secretion system apparatus protein SsaLQuickGO ontologyBLASTP
14927431493111369secretion system apparatus protein SsaMQuickGO ontologyBLASTP
149309614951412046secretion system apparatus protein SsaVQuickGO ontologyBLASTP
149513114964321302type III secretion apparatus H-transporting two-sector ATPaseQuickGO ontologyBLASTP
14964351496812378secretion system apparatus SsaOQuickGO ontologyBLASTP
14968261497167342secretion system apparatus protein SsaPQuickGO ontologyBLASTP
14971481498116969type III secretion apparatus protein YscQHrcQ familyQuickGO ontologyBLASTP
14981841498831648type III secretion apparatus protein YscRHrcR familyQuickGO ontologyBLASTP
14990951499874780type III secretion apparatus protein SpaRYscTHrcTQuickGO ontologyBLASTP
149987115009291059secretion system apparatus protein SsaUQuickGO ontologyBLASTP
150140215027751374multidrug resistance protein NorMQuickGO ontologyBLASTP
15029921503633642riboflavin synthase alpha subunitQuickGO ontologyBLASTP
150367515048231149cyclopropane-fatty-acyl-phospholipid synthaseQuickGO ontologyBLASTP
150511315063181206inner membrane transport protein YdhCQuickGO ontologyBLASTP
15064311507363933transcriptional regulator LysR familyQuickGO ontologyBLASTP
150736015083851026transcriptional repressor PurRQuickGO ontologyBLASTP