Pre_GI Gene

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Host: NC_010729 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010729:2038118 Porphyromonas gingivalis ATCC 33277, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain was isolated from human gingiva. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
203811820391521035hypothetical proteinBLASTP
20391492039763615hypothetical proteinBLASTP
20399042040566663hypothetical proteinBLASTP
20411682041605438hypothetical proteinBLASTP
204163820478956258hypothetical proteinBLASTP
20478892048422534hypothetical proteinBLASTP
20485262048987462hypothetical proteinBLASTP
204904720504441398hypothetical proteinBLASTP
20510092051110102hypothetical protein
20515882052361774hypothetical proteinBLASTP
20524652052776312hypothetical proteinBLASTP
205290720540941188hypothetical proteinBLASTP
20540912054789699hypothetical proteinBLASTP
205521320565021290S-adenosylmethionine synthaseQuickGO ontologyBLASTP