Pre_GI Gene

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Host: NC_010729 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010729:1385217 Porphyromonas gingivalis ATCC 33277, complete genome

Host Lineage: Porphyromonas gingivalis; Porphyromonas; Porphyromonadaceae; Bacteroidales; Bacteroidetes; Bacteria

General Information: This strain was isolated from human gingiva. This organism is associated with severe and chronic periodontal (tissues surrounding and supporting the tooth) diseases. Progression of the disease is caused by colonization by this organism in an anaerobic environment in host tissues and severe progression results in loss of the tissues supporting the tooth and eventually loss of the tooth itself. The black pigmentation characteristic of this bacterium comes from iron acquisition that does not use the typical siderophore system of other bacteria but accumulates hemin. Peptides appear to be the predominant carbon and energy source of this organism, perhaps in keeping with its ability to destroy host tissue. Oxygen tolerance systems play a part in establishment of the organism in the oral cavity, including a superoxide dismutase. Pathogenic factors include extracellular adhesins that mediate interactions with other bacteria as well as the extracellular matrix, and a host of degradative enzymes that are responsible for tissue degradation and spread of the organism including the gingipains, which are trypsin-like cysteine proteases.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
138521713863681152hypothetical proteinBLASTP
13864151386726312hypothetical protein
138674713877901044hypothetical proteinBLASTP
138780613893741569UDP-glucose 6-dehydrogenaseQuickGO ontologyBLASTP
13894181390377960putative peptide chain release factor RF-2QuickGO ontologyBLASTP
139065713924831827long-chain-fatty-acid-CoA ligaseQuickGO ontologyBLASTP
139263813967894152hypothetical proteinBLASTP
13970641397213150hypothetical protein
13972801397396117hypothetical protein
13974751397627153hypothetical protein
13977081397926219hypothetical protein
139804613991731128probable glycosyltransferaseQuickGO ontologyBLASTP
139955314007011149iron-containing alcohol dehydrogenaseQuickGO ontologyBLASTP
14008401401256417hypothetical protein
14014171402022606hypothetical proteinBLASTP
140210614031611056putative heptosyltransferaseQuickGO ontologyBLASTP
14031451403597453hypothetical protein
1403714140380693hypothetical protein
140435314053751023cobalamin biosynthesis proteinQuickGO ontologyBLASTP
140538914063961008probable histidinol-phosphate aminotransferaseQuickGO ontologyBLASTP
140638914078851497cobyric acid synthaseQuickGO ontologyBLASTP
14078821408448567probable cobalamin adenosyltransferaseQuickGO ontologyBLASTP