Pre_GI Gene

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Host: NC_010698 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010698:819912 Helicobacter pylori Shi470, complete genome

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori Shi470 is a clinical isolate from gastric antrum from Amerindian resident of remote Amazonian village of Shimaa, Peru. Helicobacter pylori chronically infects stomachs of billions of people worldwide, is implicated in peptic ulcer disease and gastric cancer, and is very diverse genetically. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8199128231693258cag island protein cytotoxicity-associated immunodominant antigenQuickGO ontologyBLASTP
82336282346099hypothetical protein
823481823708228cag pathogenicity island protein BQuickGO ontologyBLASTP
823876824067192cag pathogenicity island protein CQuickGO ontology
82413782423296hypothetical proteinBLASTP
824858825163306cag island proteinQuickGO ontologyBLASTP
825192825374183hypothetical proteinBLASTP
825507825644138hypothetical proteinBLASTP
826078826677600cag pathogenicity island protein SQuickGO ontologyBLASTP
826879827721843cag pathogenicity island protein cag12QuickGO ontologyBLASTP
827737828384648cag island proteinQuickGO ontologyBLASTP
828660829418759cag pathogenicity island protein VQuickGO ontologyBLASTP
8294238310301608cag island proteinQuickGO ontologyBLASTP
8310828326501569cag pathogenicity island protein cag8QuickGO ontologyBLASTP
8326658382295565cag pathogenicity island protein cag7QuickGO ontologyBLASTP
838219838353135hypothetical proteinBLASTP
838366838965600cag pathogenicity island protein ZQuickGO ontologyBLASTP
838970839962993cag pathogenicity island encoded proteinATPase proteinQuickGO ontologyBLASTP
8399718422172247cag pathogenicity island protein 5QuickGO ontologyBLASTP
842336842716381cag pathogenicity island protein cag4QuickGO ontologyBLASTP
8428558443001446cag pathogenicity island protein cag3QuickGO ontologyBLASTP