Pre_GI Gene

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Host: NC_010674 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010674:615963 Clostridium botulinum B str. Eklund 17B, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6159636181162154chitinase AQuickGO ontologyBLASTP
6184796202211743hypothetical sigma-54-dependent transcriptional regulator YgeVQuickGO ontologyBLASTP
6206026218011200M20DapE family protein YgeYQuickGO ontologyBLASTP
6218586230511194probable carbamoyltransferase YgeWQuickGO ontologyBLASTP
623365624297933carbamate kinaseQuickGO ontologyBLASTP
6243366255441209diaminopropionate ammonia-lyaseQuickGO ontologyBLASTP
6255716269021332proteoglycanQuickGO ontologyBLASTP
626916627608693YczEQuickGO ontologyBLASTP
6276806290411362hydroxydechloroatrazine ethylaminohydrolaseQuickGO ontologyBLASTP
6290796301671089dihydroorotate dehydrogenase family proteinQuickGO ontologyBLASTP
630362630736375putative endoribonuclease L-PSPQuickGO ontologyBLASTP
630817631362546hypothetical proteinBLASTP
6319036344642562selenium-dependent molybdenum hydroxylase 1QuickGO ontologyBLASTP
634470634658189hypothetical protein
6346906360811392dihydropyrimidinaseQuickGO ontologyBLASTP
636253636726474cytidinedeoxycytidylate deaminase family proteinQuickGO ontologyBLASTP
63737163966222924-hydroxybenzoyl-CoA reductase subunit alphaQuickGO ontologyBLASTP