Pre_GI Gene

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Host: NC_010674 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010674:426256 Clostridium botulinum B str. Eklund 17B, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4262564277371482putative extracellular solute-binding proteinQuickGO ontologyBLASTP
4278104289191110hypothetical proteinBLASTP
429194429400207hypothetical protein
429716430465750ribonuclease PHQuickGO ontologyBLASTP
430469431086618non-canonical purine NTP pyrophosphatase RdgBHAM1 familyQuickGO ontologyBLASTP
431098431577480phosphodiesterase familyQuickGO ontologyBLASTP
43170643178176tRNA-ProQuickGO ontologyBLASTP
43180443187774tRNA-GlyQuickGO ontology
43189143196979tRNA-ArgQuickGO ontologyBLASTP
43197343205078tRNA-HisQuickGO ontologyBLASTP
43205243212877tRNA-GlnQuickGO ontologyBLASTP
43213343221078tRNA-LysQuickGO ontologyBLASTP
43221843230487tRNA-LeuQuickGO ontology
43230843238477tRNA-GlyQuickGO ontologyBLASTP
43239943247274tRNA-GlyQuickGO ontology
43248443256178tRNA-LysQuickGO ontologyBLASTP
43256943264678tRNA-HisQuickGO ontologyBLASTP
43265143272575tRNA-GlnQuickGO ontology
43274643282378tRNA-LysQuickGO ontologyBLASTP
43282843291487tRNA-LeuQuickGO ontology
43291843299477tRNA-GlyQuickGO ontologyBLASTP
43300643307974tRNA-GlyQuickGO ontologyBLASTP
43312543320177tRNA-ArgQuickGO ontologyBLASTP
433493433648156hypothetical protein
434325435829150516S ribosomal RNAQuickGO ontologyBLASTP
43595343602977tRNA-IleQuickGO ontology
436416439325291023S ribosomal RNAQuickGO ontologyBLASTP
43938543946177tRNA-AsnQuickGO ontologyBLASTP
439787440734948polysaccharide deacetylase family proteinQuickGO ontologyBLASTP
440836441525690alkaline phosphatase synthesis transcriptional regulatory proteinphoPQuickGO ontologyBLASTP
4415304429271398alkaline phosphatase synthesis sensor protein PhoRQuickGO ontologyBLASTP
4429244443781455putative lipoproteinQuickGO ontologyBLASTP
4445684459501383TldD proteinQuickGO ontologyBLASTP
4459544472971344TldDPmbA family proteinQuickGO ontologyBLASTP
4475034493531851sulfataseQuickGO ontologyBLASTP
449536450114579hypothetical proteinBLASTP
450145451101957tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidAQuickGO ontologyBLASTP
451098451661564lipolytic enzyme G-D-S-LQuickGO ontologyBLASTP
451677452294618endodeoxyribonuclease RusA family proteinQuickGO ontologyBLASTP