Pre_GI Gene

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Host: NC_010674 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010674:3674739 Clostridium botulinum B str. Eklund 17B, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
367473936764001662sulfate permease family proteinQuickGO ontologyBLASTP
36767533677625873dihydrodipicolinate synthaseQuickGO ontologyBLASTP
36782393679042804hypothetical proteinBLASTP
36794463680195750transporterQuickGO ontologyBLASTP
36802783680958681integral membrane proteinQuickGO ontologyBLASTP
368114836812641175S ribosomal RNAQuickGO ontologyBLASTP
36813223684231291023S ribosomal RNAQuickGO ontologyBLASTP
36844613685965150516S ribosomal RNAQuickGO ontologyBLASTP
368684836869641175S ribosomal RNAQuickGO ontologyBLASTP
36870223689931291023S ribosomal RNAQuickGO ontologyBLASTP
36901613691665150516S ribosomal RNAQuickGO ontologyBLASTP
36935063693622117hypothetical protein
369361436937301175S ribosomal RNAQuickGO ontologyBLASTP
36937883696697291023S ribosomal RNAQuickGO ontologyBLASTP
36969273698431150516S ribosomal RNAQuickGO ontologyBLASTP
36990503699220171transposase familyQuickGO ontologyBLASTP
369975836998741175S ribosomal RNAQuickGO ontologyBLASTP
36999323702841291023S ribosomal RNAQuickGO ontologyBLASTP
37030713704575150516S ribosomal RNAQuickGO ontologyBLASTP
370579737059131175S ribosomal RNAQuickGO ontologyBLASTP
37059713708880291023S ribosomal RNAQuickGO ontologyBLASTP
37090813710585150516S ribosomal RNAQuickGO ontologyBLASTP
37108633711762900phospholipase patatin familyQuickGO ontologyBLASTP
37117963712614819protein YqfLQuickGO ontologyBLASTP
37129893713735747hypothetical proteinBLASTP
371375037149371188GTP-binding proteinQuickGO ontologyBLASTP
3715307371538478tRNA-LysQuickGO ontologyBLASTP
371539037155061175S ribosomal RNAQuickGO ontologyBLASTP
37157803716514735chemotaxis MotB proteinQuickGO ontologyBLASTP
37165193717295777chemotaxis protein MotAQuickGO ontologyBLASTP
37176143718561948L-lactate dehydrogenaseQuickGO ontologyBLASTP
3718975371905278tRNA-LysQuickGO ontologyBLASTP
371905837191741175S ribosomal RNAQuickGO ontologyBLASTP
37193023722211291023S ribosomal RNAQuickGO ontologyBLASTP