Pre_GI Gene

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Host: NC_010674 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010674:2328307 Clostridium botulinum B str. Eklund 17B, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
23283072329032726hypothetical proteinBLASTP
23292012329362162hypothetical protein
23297502329935186LexA DNA binding domainQuickGO ontologyBLASTP
23306882331488801putative phage lysozymeQuickGO ontologyBLASTP
23315472331720174hypothetical proteinBLASTP
23317392331951213hypothetical protein
23323692332587219hypothetical proteinBLASTP
23326122332902291hypothetical protein
233290423343551452hypothetical proteinBLASTP
233436723361091743putative phage endopeptidaseQuickGO ontologyBLASTP
23361062336783678putative phage tail componentQuickGO ontologyBLASTP
233679923402633465tail tape measure proteinQuickGO ontologyBLASTP
23403142340577264hypothetical proteinBLASTP
23405802340903324hypothetical proteinBLASTP
23409062341487582hypothetical proteinBLASTP
23414902341810321hypothetical proteinBLASTP
23418032342192390hypothetical proteinBLASTP
23421922342527336hypothetical proteinBLASTP
23425272342832306Gp6 proteinQuickGO ontologyBLASTP
234284723440431197major capsid protein aQuickGO ontologyBLASTP
23440432344786744peptidase S14 ClpPQuickGO ontologyBLASTP
234477923459361158phage portal protein HK97 familyQuickGO ontologyBLASTP
23459792346263285hypothetical protein
234627723479231647putative phage terminase large subunitQuickGO ontologyBLASTP
23479132348413501hypothetical proteinBLASTP