Pre_GI Gene

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Host: NC_010674 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010674:1986000 Clostridium botulinum B str. Eklund 17B, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
19861581986541384hypothetical proteinBLASTP
19870851987876792collagenolytic proteaseQuickGO ontologyBLASTP
19879321988105174hypothetical proteinBLASTP
19881181988318201UviB homologous proteinQuickGO ontologyBLASTP
19883831989168786cell adhesion domain-containing proteinQuickGO ontologyBLASTP
19893931989947555hypothetical protein
19900291990238210hypothetical protein
19903341990531198hypothetical protein
19905441990882339hypothetical protein
199090019922911392putative tail fiber proteinQuickGO ontologyBLASTP
19922911992908618hypothetical proteinBLASTP
199289819939651068putative conserved hypothetical proteinQuickGO ontologyBLASTP
19939771994432456hypothetical proteinBLASTP
19944321994785354hypothetical protein
199479719962541458NlpCP60 family proteinQuickGO ontologyBLASTP
19962541997024771hypothetical proteinBLASTP
19970331997752720hypothetical proteinBLASTP
199776119996561896hypothetical protein
19996701999849180hypothetical protein
19998912000337447hypothetical protein
20003892000847459hypothetical protein
200086320019421080XkdK proteinQuickGO ontologyBLASTP
20019992002436438hypothetical protein
20024452002849405hypothetical proteinBLASTP
20028422003186345hypothetical protein
20031892003476288hypothetical proteinBLASTP
20034912004426936prophage proteinQuickGO ontologyBLASTP
20044632005062600hypothetical proteinBLASTP
20051602005468309hypothetical protein
20055012005674174hypothetical protein
20057342005955222putative Guanosine polyphosphate pyrophosphohydrolasesynthetase homologQuickGO ontology
20059912006194204hypothetical proteinBLASTP
20062492007130882hypothetical proteinBLASTP
200712020084841365hypothetical proteinBLASTP