Pre_GI Gene

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Host: NC_010674 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010674:1496500 Clostridium botulinum B str. Eklund 17B, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
149657514977231149alcohol dehydrogenase iron-containingQuickGO ontologyBLASTP
14982211499057837transcriptional regulatory proteinQuickGO ontologyBLASTP
149963715007341098membrane spanning proteinQuickGO ontologyBLASTP
15007341501000267hypothetical proteinBLASTP
15010251501321297propanediol utilization protein PduAQuickGO ontologyBLASTP
15013481501653306propanediol utilization protein PduAQuickGO ontologyBLASTP
150172915032191491aldehyde-alcohol dehydrogenase 2QuickGO ontologyBLASTP
150327515058152541formate C-acetyltransferaseQuickGO ontologyBLASTP
15059831506936954benzylsuccinate synthase activating enzymeQuickGO ontologyBLASTP
15069761507329354ethanolamine utilization protein EutSQuickGO ontologyBLASTP
15073261507784459lysine-sensitive aspartokinase IIIQuickGO ontologyBLASTP
15077841508452669hypothetical proteinBLASTP
15084341509279846ethanolamine utilization protein EutJQuickGO ontologyBLASTP
15092951509597303microcompartments proteinQuickGO ontologyBLASTP
15095941509857264ethanolamine utilization protein EutNcarboxysome structural protein CcmlQuickGO ontologyBLASTP
150987515112031329respiratory-chain NADH dehydrogenase domain 51 kda subunitQuickGO ontologyBLASTP
15112051511753549microcompartments proteinQuickGO ontologyBLASTP
15118111512473663transcriptional regulatorQuickGO ontologyBLASTP
15124961513254759bacterial microcompartments family proteinQuickGO ontologyBLASTP
151329315148521560acetaldehyde dehydrogenase acetylatingQuickGO ontologyBLASTP
15148531515503651propanediol utilization proteinQuickGO ontologyBLASTP
15155601515850291propanediol utilization protein PduAQuickGO ontologyBLASTP
15161191516508390iron-binding protein hemerythrinQuickGO ontologyBLASTP
151701015184041395xanthineuracil permease family proteinQuickGO ontologyBLASTP
15188271519507681hydrogenase accessory protein HypBQuickGO ontologyBLASTP
151952915222192691pyridine nucleotide-disulphide oxidoreductase family proteinQuickGO ontologyBLASTP
15223281522669342hydrogenase nickel incorporation proteinQuickGO ontologyBLASTP
152272015237421023putative iron chelate uptake ABC transporter solute-binding proteinQuickGO ontologyBLASTP
152374215248241083Fe uptake system integral membrane proteinQuickGO ontologyBLASTP
15248241525660837iron chelate uptake ABC transporter FeCT family ATP-binding proteinQuickGO ontologyBLASTP