Pre_GI Gene

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Host: NC_010674 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010674:1170264 Clostridium botulinum B str. Eklund 17B, complete genome

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: Clostridium botulinum B str. Eklund 17B is a nonproteolytic botulism neurotoxin B strain. This strain was isolated from marine sediments taken off the coast of Washington, USA and was not associated with botulism. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11702641171178915hypothetical protein
11713101171876567snare associated golgi proteinQuickGO ontologyBLASTP
11720301172956927conserved protein tetratricopeptide repeat family proteinQuickGO ontologyBLASTP
11731481173651504hypothetical proteinBLASTP
11737971174447651putative lipoproteinQuickGO ontologyBLASTP
11746991175148450MarR-family transcriptional regulatorQuickGO ontologyBLASTP
117516311761319693-oxoacyl-acyl-carrier-protein synthase IIIQuickGO ontologyBLASTP
11762031176427225acyl carrier protein homologQuickGO ontologyBLASTP
11765371177478942putative enoyl-acyl-carrier-protein reductase IIQuickGO ontologyBLASTP
11774711178412942malonyl CoA-acyl carrier protein transacylaseQuickGO ontologyBLASTP
117843311791737413-oxoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP
1179191118043212423-oxoacyl-acyl-carrier-protein synthase 2QuickGO ontologyBLASTP
11804441180938495acetyl-CoA carboxylase biotin carboxyl carrier proteinQuickGO ontologyBLASTP
11809441181372429beta-hydroxyacyl-acyl-carrier-protein dehydratase FabZQuickGO ontologyBLASTP
118138211827341353acetyl-CoA carboxylase biotin carboxylaseQuickGO ontologyBLASTP
11827271183602876acetyl-CoA carboxylase carboxyl transferase beta subunitQuickGO ontologyBLASTP
11835951184419825acetyl-CoA carboxylase carboxyl transferase alpha subunitQuickGO ontologyBLASTP
11846001185541942hypothetical proteinBLASTP
11855751185988414HutP superfamilyQuickGO ontologyBLASTP
11862731186389117hypothetical protein
11863861187186801oxidoreductase short chain dehydrogenasereductase familyQuickGO ontologyBLASTP
118760011901552556selenium-dependent molybdenum hydroxylase 1QuickGO ontologyBLASTP
11902411190918678hypothetical proteinBLASTP
119091811919401023molybdopterin biosynthesis proteinQuickGO ontologyBLASTP
11919541192433480molybdenum cofactor biosynthesis protein CQuickGO ontologyBLASTP