Pre_GI Gene

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Host: NC_010660 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010660:86445 Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
8644586771327IS629 transposase orfAQuickGO ontologyBLASTP
8676887658891IS629 transposase orfBQuickGO ontologyBLASTP
88027894811455OspC3QuickGO ontologyBLASTP
8981990121303ISSd1 transposase orfAB fusionQuickGO ontologyBLASTP
9015790975819IS3 family element transposase orfBQuickGO ontologyBLASTP
91940930551116putative transposaseQuickGO ontologyBLASTP
93146943421197transposaseQuickGO ontologyBLASTP
9453494971438transposaseQuickGO ontologyBLASTP
9505995448390IS66 family element orf1QuickGO ontologyBLASTP
9544595792348IS66 family element orf2QuickGO ontologyBLASTP
95841973791539IS66 family element transposaseQuickGO ontologyBLASTP
9893599066132hypothetical protein
99340100119780IpaJ invasion plasmid antigenQuickGO ontology
100137100295159hypothetical protein
100296100409114hypothetical protein
100684100815132hypothetical protein
100845101015171hypothetical protein
101065101994930virulence regulon transcriptional activator VirBQuickGO ontologyBLASTP
102211102447237acyl carrier proteinQuickGO ontologyBLASTP
1024511043521902invasin protein IpaAQuickGO ontologyBLASTP
104361105359999invasin protein IpaDQuickGO ontologyBLASTP
1054101065011092invasin protein IpaCQuickGO ontologyBLASTP
1065211082631743IpaBQuickGO ontologyBLASTP
108269108736468chaperone protein IpgCQuickGO ontologyBLASTP
108794109420627IpgB1QuickGO ontologyBLASTP