Pre_GI Gene

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Host: NC_010660 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010660:33109 Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3310933594486transposase and inactivated derivativesQuickGO ontologyBLASTP
3362133767147Aec53QuickGO ontologyBLASTP
33883351001218reverse transcriptaseQuickGO ontologyBLASTP
3557835715138transposase familyQuickGO ontologyBLASTP
3668637012327IS629 transposase orfAQuickGO ontologyBLASTP
3718037308129hypothetical protein
3766238081420IS66 family element orf1QuickGO ontologyBLASTP
3809338437345hypothetical proteinBLASTP
38459400511593IS66 family element transposaseQuickGO ontologyBLASTP
4009240577486acetyltransferase gnat familyQuickGO ontologyBLASTP
4056540849285hypothetical proteinBLASTP
4152241824303IS911 transposase orfAQuickGO ontologyBLASTP
4463745026390IS66 family element orf1QuickGO ontologyBLASTP
4552346428906IS2 transposase orfBQuickGO ontologyBLASTP
4687046986117hypothetical protein
4721947857639hypothetical proteinBLASTP
48513501141602transposase familyQuickGO ontologyBLASTP
5061950945327IS1203 transposase orfAQuickGO ontologyBLASTP