Pre_GI Gene

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Host: NC_010660 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010660:175200 Shigella boydii CDC 3083-94 plasmid pBS512_211, complete sequence

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
1752001762881089putative glycosyl transferase group 1 family proteinQuickGO ontologyBLASTP
176293177243951hypothetical proteinBLASTP
177308178252945lipid A biosynthesis KDO2-lauroyl-lipid IVA acyltransferaseQuickGO ontologyBLASTP
179094179597504IS1 transposase orfBQuickGO ontologyBLASTP
179672179947276hypothetical proteinBLASTP
182245182964720TrbHQuickGO ontologyBLASTP
188255189001747type IV secretion-like conjugative transfer system pilin acetylase TraXQuickGO ontologyBLASTP
189005189616612fertility inhibition protein FinOQuickGO ontologyBLASTP
189592189714123hypothetical protein
189747189959213hypothetical proteinBLASTP
190710190916207hypothetical proteinBLASTP
191735192325591hypothetical proteinBLASTP
192565192825261replication regulatory protein RepA2QuickGO ontologyBLASTP
19294219303190misc_RNAQuickGO ontology
193116193973858IncFII replication initiation protein RepA1QuickGO ontologyBLASTP
194036194161126hypothetical protein
195071195295225hypothetical proteinBLASTP
1954511966501200IS1294 transposaseQuickGO ontologyBLASTP
196660196848189hypothetical proteinBLASTP
196863197210348transposase subfamilyQuickGO ontologyBLASTP
197172197546375transposase familyQuickGO ontologyBLASTP
197532197654123hypothetical protein
197791198306516transposase IS4 familyQuickGO ontologyBLASTP
198186198635450putative transposaseQuickGO ontologyBLASTP
1990602005141455OspC2QuickGO ontologyBLASTP
200663200893231hypothetical proteinBLASTP
2009632021471185IS1294 transposaseQuickGO ontologyBLASTP
202109202435327IS629 transposase orfAQuickGO ontologyBLASTP
202432203322891IS629 transposase orfBQuickGO ontologyBLASTP
203362203484123transposaseQuickGO ontologyBLASTP
203465203737273hypothetical proteinBLASTP
203731203865135invasion plasmid antigenQuickGO ontologyBLASTP
204009204311303hypothetical proteinBLASTP
204302204784483acetyltransferase gnat familyQuickGO ontologyBLASTP