Pre_GI Gene

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Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:4494103 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
44941034494546444DNA polymerase III chi subunitQuickGO ontologyBLASTP
449454644974012856valyl-tRNA synthetaseQuickGO ontologyBLASTP
44984814498984504IS1 transposase orfBQuickGO ontologyBLASTP
44990594499292234transposaseQuickGO ontologyBLASTP
45001714500587417hypothetical proteinBLASTP
450074945017531005ornithine carbamoyltransferaseQuickGO ontologyBLASTP
45018254502505681hypothetical proteinBLASTP
45025804503083504IS1 transposase orfBQuickGO ontologyBLASTP
45043724504824453hypothetical proteinBLASTP
45049694505562594transcriptional regulator TetR familyQuickGO ontologyBLASTP
45056334506346714oxidoreductase short chain dehydrogenasereductase familyQuickGO ontologyBLASTP
45064774506872396endoribonuclease L-PSP family proteinQuickGO ontologyBLASTP
45071514507285135pyrBI operon leader peptideQuickGO ontologyBLASTP
45072894508224936aspartate carbamoyltransferase catalytic subunitQuickGO ontologyBLASTP
45082374508698462aspartate carbamoyltransferase regulatory subunitQuickGO ontologyBLASTP
45087714509157387putative endoribonuclease L-PSPQuickGO ontologyBLASTP
450936345120592697magnesium-translocating P-type ATPaseQuickGO ontologyBLASTP