Pre_GI Gene

Some Help

Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:4257310 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
42573104257678369diacylglycerol kinaseQuickGO ontologyBLASTP
425784942602722424glycerol-3-phosphate acyltransferaseQuickGO ontologyBLASTP
426042742612998734-hydroxybenzoate polyprenyl transferaseQuickGO ontologyBLASTP
42613124261809498chorismate lyaseQuickGO ontologyBLASTP
426230542634801176transposaseQuickGO ontologyBLASTP
42637444264085342hypothetical proteinBLASTP
42639694264136168hypothetical protein
42641304264507378IS1 transposase orfBQuickGO ontologyBLASTP
42648784265711834hypothetical proteinBLASTP
42660424266227186transposaseQuickGO ontologyBLASTP
42663024266805504IS1 transposase orfBQuickGO ontologyBLASTP
42668814267384504hypothetical proteinBLASTP
42677864268499714class B acid phosphataseQuickGO ontologyBLASTP
42686104269026417hypothetical proteinBLASTP
42690304269386357hypothetical proteinBLASTP
426942142722432823excinuclease ABC A subunitQuickGO ontologyBLASTP
42724974273012516single-stranded DNA-binding proteinQuickGO ontologyBLASTP
42731114273392282hypothetical proteinBLASTP
42738224274562741hypothetical proteinBLASTP
42745444274732189putative IS1 encoded proteinQuickGO ontologyBLASTP