Pre_GI Gene

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Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:3774110 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
37741103775069960polysaccharide deacetylase family proteinQuickGO ontologyBLASTP
377505637760901035glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
377632937773541026L-threonine 3-dehydrogenaseQuickGO ontologyBLASTP
3777364377856011972-amino-3-ketobutyrate coenzyme A ligaseQuickGO ontologyBLASTP
37787743779706933ADP-glyceromanno-heptose 6-epimeraseQuickGO ontologyBLASTP
377971637807621047lipopolysaccharide heptosyltransferase IIQuickGO ontologyBLASTP
37807663781746981lipopolysaccharide heptosyltransferase IQuickGO ontologyBLASTP
378181637830691254O-antigen polymeraseQuickGO ontologyBLASTP
37831153784098984glycosyl transferase group 2 family proteinQuickGO ontologyBLASTP
378418337852081026lipopolysaccharide 12-galactosyltransferaseQuickGO ontologyBLASTP
37852343785926693lipopolysaccharide core biosynthesis protein RfaYQuickGO ontologyBLASTP
37859363786931996lipopolysaccharide 12-glucosyltransferaseQuickGO ontologyBLASTP
378694837879641017lipopolysaccharide 13-galactosyltransferaseQuickGO ontologyBLASTP
37879803788777798lipopolysaccharide core biosynthesis protein RfaPQuickGO ontologyBLASTP
378877037898941125lipopolysaccharide core biosynthesis protein RfaGQuickGO ontologyBLASTP
378989137909491059lipopolysaccharide core biosynthesis glycosyltransferase RfaQQuickGO ontologyBLASTP
3791362379263912783-deoxy-D-manno-octulosonic-acid transferaseQuickGO ontologyBLASTP
37926473793126480pantetheine-phosphate adenylyltransferaseQuickGO ontologyBLASTP
37931653793974810formamidopyrimidine-DNA glycosylaseQuickGO ontologyBLASTP
37940723794239168ribosomal protein L33QuickGO ontologyBLASTP
37942603794496237ribosomal protein L28QuickGO ontologyBLASTP
37947133795381669DNA repair protein RadCQuickGO ontologyBLASTP
379555337967731221phosphopantothenoylcysteine decarboxylasephosphopantothenate--cysteine ligaseQuickGO ontologyBLASTP
37967543797209456dUTP diphosphataseQuickGO ontologyBLASTP
37973163797912597transcriptional regulator domain protein TetR familyQuickGO ontologyBLASTP
37979493798590642orotate phosphoribosyltransferaseQuickGO ontologyBLASTP
37986563799372717ribonuclease PHQuickGO ontologyBLASTP