Pre_GI Gene

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Host: NC_010658 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_010658:3622610 Shigella boydii CDC 3083-94, complete genome

Host Lineage: Shigella boydii; Shigella; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain (strain BS512; serotype 18) was originally isolated from a 12-year-old boy in Arizona, USA by Dr. Nancy Stockbine. It is a member of Group 1 as determined by limited sequence analysis and can invade HeLa cells. Pathogenicity and virulence have been verified during in vitro experimentation, and multiple plasmids are present in this strain. This genus is named for the Japanese scientist (Shiga) who first discovered these organisms in the 1890s. They are closely related to the Escherichia group, and may be considered the same species. These organisms are human-specific pathogens that are transmitted via contaminated food and water and are the leading causes of endemic bacillary dysentery, causing over 160 million cases of infection and 1 million deaths yearly worldwide. The bacteria infect the epithelial lining of the colon, causing acute inflammation by entering the host cell cytoplasm and spreading intercellularly. Shigella spp. are extremely virulent organisms that can cause an active infection after a very low exposure. Both the type III secretion system, which delivers effector molecules into the host cell, and some of the translocated effectors such as the invasion plasmid antigens (Ipas), are encoded on the plasmid. The bacterium produces a surface protein that localizes to one pole of the cell (IcsA) which binds to and promotes actin polymerization, resulting in movement of the bacterium through the cell cytoplasm, and eventually to neighboring cells, which results in inflammatory destruction of the mucosal lining. This species is uncommon except in India, where it was first isolated. Progression to clinical dysentery occurs in most patients infected with this organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
362261036250572448glycogen phosphorylaseQuickGO ontologyBLASTP
36251573625468312IS4 ORFQuickGO ontologyBLASTP
36259363626286351IS66 family transposase orfBQuickGO ontologyBLASTP
362631736279091593IS66 family element transposaseQuickGO ontologyBLASTP
36280953629000906IS2 transposase orfBQuickGO ontologyBLASTP
36292433629449207putative IS1 encoded proteinQuickGO ontologyBLASTP
36295243630027504IS1 transposase orfBQuickGO ontologyBLASTP
36317643632330567outer membrane lipoprotein Slp familyQuickGO ontologyBLASTP
36324863633016531transcriptional regulator DctRQuickGO ontologyBLASTP
36330583633705648putative Mg2 transporter-C MgtC family proteinQuickGO ontologyBLASTP
36337693634107339HdeB proteinQuickGO ontologyBLASTP
36342113634543333hns-dependent expression protein A HdeAQuickGO ontologyBLASTP
36347983635370573putative HdeD proteinQuickGO ontologyBLASTP
36361693636696528transcriptional regulator GadEQuickGO ontologyBLASTP
363703536381921158multidrug resistance protein MdtEQuickGO ontologyBLASTP
363821736413303114multidrug resistance protein MdtFQuickGO ontologyBLASTP